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Demolished or closed Strip casinos and hotels
Aladdin Hotel and Casino: Opened in 1963 as the Tally Ho, became the King’s Crown in 1965, the Aladdin in 1966, and was demolished in 1998, and reopened in 2000. In 2003, the Aladdin was renamed Planet Hollywood.
Big Red’s Casino: Closed in 1982. Property developed for CBS Sports World Casino. Changed name to Sports World Casino after CBS threatened to sue. Closed in 2001, now a shopping center. 
Boardwalk Hotel and Casino: Closed in January 6, 2006, demolished May 9, 2006 to make way for CityCenter.
Desert Inn (and golf course): Closed in August 28, 2000, demolished in 2004, now Wynn Las Vegas; golf course retained and improved.
The Dunes (and golf course): Closed in January 26, 1993, demolished in 1993, now Bellagio, and golf course of Dunes become part of Monte Carlo, New York-New York, City Center, now demolished Boardwalk, and Cosmopolitan.
El Rancho (formerly Thunderbird/Silverbird): Closed in 1992 and demolished in 2000. Now the unfinished Fontainebleau.
El Rancho Vegas: Burned down in 1960. The Hilton Grand Vacation Club timeshare now exists on the south edge of the site where the resort once stood; the remainder remains vacant.
Glass Pool Inn: Demolished in 2006. It was called Mirage Motel until 1988 and changed names due to The Mirage opening down the Strip in 1989.
Hacienda: Closed in 1996, demolished in 1996, now Mandalay Bay. A separate Hacienda now exists outside of Boulder City, formerly the Gold Strike Inn.
Holy Cow Casino Cafe and Brewery: First micro brewery in Las Vegas. Closed in 2002, property currently vacant.
Jackpot Casino: Closed in 1977, now the Sahara.
Klondike Hotel & Casino: Closed in 2006, demolished in 2008.
Lucky Slots Casino: Closed in 1981, now a shopping center.
Lotus Inn Hotel & Casino: Closed in 1978, now a Rodeway Inn.
Money Tree Casino: Closed in 1979, now Bonanza Gift & Souvenir Shops.
Marina Hotel and Casino: Closed, adapted into MGM Grand, now the West Wing of the MGM Grand.
The New Frontier: Closed July 16, 2007, demolished November 13, 2007. Was to be replaced by the Las Vegas Plaza, but that project was canceled.
Sahara Hotel and Casino: Closed May 16, 2011. The owner of the hotel, Sam Nazarian, left open the possibility of reopening the property at a later date. 
San Souci: Closed in 1962 for the Castaways, which itself was demolished in 1987. Now Treasure Island.
The Sands: Closed in June 30, 1996, demolished in 1996, now The Venetian.
Silver City Hotel & Casino: Closed in 1999, now the Silver City Shopping Center.
Silver Slipper: Demolished in 1988 for a parking lot. Now the site of the Desert Inn Road Arterial.
Stardust Resort & Casino: Closed November 1, 2006, demolished March 13, 2007. Now the incomplete Echelon Place.
Tally Ho Hotel: Closed in 1966. Became the Aladdin, which in 2007 became Planet Hollywood.
Vacation Village Resort & Casino: Closed in 2002, demolished in 2006. Site of the new Town Square development.
Vegas World: Demolished in 1995 and rebuilt as the Stratosphere; parts of the old Vegas World still remain.
Westward Ho Hotel and Casino: Closed in 2005, demolished in 2006.